Description
The combination of sulfadiazine and trimethoprim acts synergistic and bactericidal against a broad range of Gram-positive and Gram-negative bacteria and erythromycin even broadens the range to E.coli, Pasteurella, Salmonella , Staphylococcus spp., Streptococcus spp., Haemophilus paragallinarum, Campylobacter, Rickettsia spp , Chlamidia spp. and mycoplasma. Erythromycin is a macrolide antibiotic it binds reversibly to the 50S subunit of ribosomes, resulting in the blockage of transpeptidation or translocation reactions, leading to impaired and/or inhibited protein synthesis and, hence, to inhibited cell growth. Sulfadiazine and Trimetroprim both affect bacterial purine (building blocks of DNA) synthesis in a different stage on the same pathway by inhibiting the metabolism of folic acid which is needed for purine synthesis. As a result a double blockage is accomplished and cell growth is inhibited. Gallitrim WS is specially indicated against the below mentioned diseases while other antibiotics and chemotherapeutics do not work effectively in cases of resistance problem.
